Nanosensor Detection of an Immunoregulatory Tryptophan Influx/Kynurenine Efflux Cycle
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چکیده
منابع مشابه
Nanosensor Detection of an Immunoregulatory Tryptophan Influx/Kynurenine Efflux Cycle
Mammalian cells rely on cellular uptake of the essential amino acid tryptophan. Tryptophan sequestration by up-regulation of the key enzyme for tryptophan degradation, indoleamine 2,3-dioxygenase (IDO), e.g., in cancer and inflammation, is thought to suppress the immune response via T cell starvation. Additionally, the excreted tryptophan catabolites (kynurenines) induce apoptosis of lymphocyte...
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ژورنال
عنوان ژورنال: PLoS Biology
سال: 2007
ISSN: 1545-7885
DOI: 10.1371/journal.pbio.0050257